NTM (NONTUBERCULOUS MYCOBACTERIA) LUNG INFECTIONS
What is NTM?
NTM stands for nontuberculous mycobacteria. NTM is found in the environment (soil and water) and can lead to serious lung infections.1-3
NTM Clinical Trial
NTM Clinical Trial Insmed is conducting the INS-212 CONVERT™ Study, a global randomized, Phase III, open-label study in adult patients with nontuberculous mycobacterial (NTM) lung infection caused by Mycobacterium avium complex (MAC) that is refractory to treatment.9
1 Young JD, Balagopal A, Reddy NS, Schlesinger LS. Differentiating colonization from infection can be difficult. J Respir Dis. 2007;28(1):7-18.
2 Adjemian J, Olivier KN, Seitz AE, Holland SM, Prevots DR. Prevalence of nontuberculous mycobacterial lung disease in U.S. Medicare beneficiaries. Am J Respir Crit Care Med. 2012;185(8):881-886.
3 Lee M-R, Yang C-Y, Chang K-P, et al. Factors associated with lung function decline in patients with non-tuberculous mycobacterial pulmonary disease. PLoS One. 2013;8(3):e58214.
4 Adjemian J, Prevots DB, Gallagher J, Heap K, Gupta R, Griffith D. Lack of adherence to evidence-based treatment guidelines for nontuberculous mycobacterial lung disease. Ann Am Thorac Soc. 2014;11(1):9-16.
5 Griffith DE, Aksamit T, Brown-Elliott BA, et al; ATS Mycobacterial Diseases Subcommittee. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007;175(4):367- 416.
6 Winthrop KL, McNelley E, Kendall B, et al. Pulmonary nontuberculous mycobacterial disease prevalence and clinical features. Am J Respir Crit Care Med. 2010;182(7):977- 982.
7 Abraham K, Dufour R, McDermott KJ, Tarr A. Pulmonary nontuberculous mycobacterial infections: healthcare resource utilization and costs in Medicare patients at a US health plan. Poster presented at: Academy of Managed Care Pharmacy (AMCP) Nexus Conference; October 26-29, 2015; Orlando, Florida.
8 Mehta M, Marras TK. Impaired health-related quality of life in pulmonary nontuberculous mycobacterial disease. Respir Med. 2011;105(11):1718-1725.
9 Clinicaltrials.gov: https://clinicaltrials.gov/ct2/show/results/NCT02344004?term=insmed+and+NTM&rank =2. Published September 27, 2016. Accessed September 28, 2016.